MELANOMA BRIDGE
December 2nd - 4th, 2021
SCIENTIFIC PROGRAM
Thursday, Dec 2nd, 2021
MELANOMA BRIDGE OPENING SESSION**
Chairpersons: Paolo A. Ascierto, Francesco Marincola
07:10 pm
Lecture: A life spent for ImmunoTherapy **
Tara Withington
07:30 pm
Lecture: Integrated multi-omic functional tumor profiling for clinical decision
support**
Reinhard Dummer
Friday, Dec 3rd, 2021
09:00 am
Introduction and objectives
Paolo A. Ascierto
SESSION
HOW COVID-19 IMPACTED ON OUR DAILY PRACTICE BOTH CLINICAL
AND RESEARCH
Chairpersons: Bernard A. Fox, Igor Puzanov
09:05 am
Clinical outcomes in cancer patients with COVID-19
Iman Osman
09:20 am
The experience at Melanoma Unit of INT Pascale of Napoli
Paolo A. Ascierto
09:35 am
VISTA as a target for immunotherapy
Marc Ernstoff
09:50 am
Addressing vulnerabilities and innovation in cancer at the time of COVID-19
Solange Peters
10:05 am
Discussion
10:35 am
SYMPOSIUM – Optimizing Melanoma Patient Care in 2021
Chairperson: Paolo A. Ascierto
Translating evidence to practice: factors impacting treatment decision in melanoma
BRAF+ patients, Axel Hauschild
Digital health solutions in melanoma patient care: benefits, opportunities and
challenges, Christian Blank
11:25 am
Coffee Break**
11:35 am
SYMPOSIUM – Adjuvant Therapy in Melanoma
Chairperson: Paolo A. Ascierto
The expanding landscape of adjuvant therapies in melanoma,
Alexander M.M. Eggermont, Paolo A. Ascierto
SESSION
MELANOMA IS MODEL FOR CANCER RESEARCH
Chairpersons: Giuseppe Masucci, Magdalena Thurin
12.25 pm
Microbiota-centered interventions for the next generation I-O
Laurence Zitvogel
12:40 pm
HLA class I defects in melanoma cells. Molecular mechanisms and clinical relevance
Soldano Ferrone
12:55 pm
Evaluating the cancer surfaceome: a possible strategy to identify targets and
monitor immunity
Bernard A. Fox
01:10 pm
Translational research for precision immuno-oncology in melanoma
Olivier Michielin
01:25 pm
Gene expression profiling assays in the risk assessment of primary melanoma
Claus Garbe
01:40 pm
Discussion
01:55 pm
Lunch**
02:45 pm
Mechanisms of success versus failure of cancer immunotherapy
Thomas Gajewski
03:00 pm
Novel humanized mouse model to study mechanisms of immune-related toxicities
Michelle Krogsgaard
03:15 pm
Lymphatic transport and the intersection of melanoma immunity and metastasis
Amanda Lund
03:30 pm
A predictive model of analysis in Real World Data related to metastatic melanoma
patients treated with immunotherapy
Gabriele Madonna
03:45 pm
The state of Microbiome/Fecal Transplant
Omid Hamid
04:00 pm
Perspectives in uveal melanoma
Richard D. Carvajal
04:15 pm
Electrochemotherapy
Corrado Caracò
04:30 pm
Discussion
04:50 pm
Coffee Break**
GREAT DEBATE SESSION
Chairpersons: Paolo A. Ascierto, Corrado Caracò, Iman Osman, Igor Puzanov
05:00 pm
Adoptive cell therapy VS bispecific antibodies in melanoma
Nikhil Khushalani, Piotr Rutkowski
05:30 pm
Discussion
05:40 pm
MAPK inhibition VS immunotherapy on adjuvant setting in melanoma
Janice Mehnert, Caroline Robert
06:10 pm
Discussion
MELANOMA BRIDGE
December 2nd - 4th, 2021
SCIENTIFIC PROGRAM
Saturday, Dec 4th, 2021
GREAT DEBATE
Chairpersons: Paolo A. Ascierto, Corrado Caracò, Iman Osman, Igor Puzanov
09:00 am
Could corticosteroids used for the management of side effects have an impact on
the outcome of melanoma patients: Yes or No?
Georgina Long, Christian Blank
09:30 am
Discussion
09:40 am
PD1 combo with CTLA4 or LAG3: which one for which patient?
Jason Luke, Paolo A. Ascierto
10:10 am
Discussion
SESSION
EMERGENT STRATEGIES
Chairpersons: Nicola Normanno, Giuseppe Palmieri
10:20 am
Neoadjuvant in melanoma
Christian Blank
10:35 am
Exploring the activity of BRAF-/MEK-inhibition beyond currently approved indications
Bart Neyns
10:50 am
Developing a new antibody targeting regulatory T cells in cancer
Sergio Quezada
11:05 am
Stability of melanoma cell-surface PD-L1 as rate-limiting to therapeutic resistance
development
Roger Lo
11:20 am
Coffee Break**
11:30 am
Strategies to overcome adaptive resistance to MAPK-directed therapies in melanoma
Poulikos Poulikakos
11:45 am
Role of tumor metabolism
Bradley Reinfeld
12:00 pm
Shall we continue to fight the dragon or try to kill its eggs?
Jean-Jacques Grob
12:15 pm
Discussion
12:30 pm
SYMPOSIUM – The role of neo-adjuvant and adjuvant immunotherapy for the
treatment of patients with melanoma
Chairpersons: Paolo A. Ascierto
Jeffrey Weber, Paolo A. Ascierto
01.20 pm
Lunch**
02.10 pm
SYMPOSIUM – BRAF metastatic melanoma patients
Chairperson: Paolo A. Ascierto
Pharmacokinetics and overview on updated clinical data, Reinhard Dummer
Triple combinations and treatment sequencing, Paolo A. Ascierto
GREAT DEBATE
Chairpersons: Paolo A. Paolo A. Ascierto, Corrado Caracò, Iman Osman, Igor Puzanov,
Alessandro Testori
03.00 pm
Brain metastases: do you need radiation? Yes or No
Sandra Demaria, Hussein A. Tawbi
03.30 pm
Discussion
03.40 pm
Telemedicine vs face-to-face visit
Allison Betof, Janice Mehnert
04.10 pm
Discussion
04.20 pm
Linfo-adenectomy: before or later?
Corrado Caracò, Jeffrey E. Gershenwald
04.50 pm
Discussion
05.00 pm
What we’ll do on Monday?
Sanjiv S. Agarwala
05.15 pm
Conclusions
Paolo A. Ascierto, Corrado Caracò, Iman Osman, Igor Puzanov
